A graphic of a purple and magenta Cas9 protein, which is a somewhat round, but uneven, ball, bound to a yellow and orange ...

Most gene-editing tools are blind to context. Point them at a DNA sequence and they cut, whether that sequence sits inside a ...

A compact Cas12f nuclease shows high editing efficiency in human cells, with structural insights enabling an engineered variant potentially suited for future AAV‑compatible delivery.

The CRISPR-Cas gene-editing system has long been the focus of research as a promising tool in genome editing. However, the ...

CRISPR functions as a programmable genetic memory system derived from bacterial immune defenses against viral infections. Guide RNA allows for rapid multiplexed targeting compared to older ...

Gene editing is a numbers game. For any genetic tweaks to have notable impact, a sufficient number of targeted cells need to have the disease-causing gene deleted or replaced. Despite a growing ...

Tomato (Solanum lycopersicum L.) is one of the most widely cultivated and consumed vegetables globally. Its fruits is highly valued for its vibrant color, culinary versatility, and nutritional ...

Researchers from Japan have established a new in vivo genome-editing system, CRISPR–Cas3, as a promising therapeutic approach for ATTR Genetic disorders occur due to alterations in the primary genetic ...

At 3 months old, Victoria Gray wouldn’t stop crying. Blood tests brought devastating news: she had sickle cell disease, a genetic blood disorder that blocks blood flow and oxygen delivery to the body.

A graphic representation of a round, lumpy, blue protein and a single, comblike, purple strand of RNA interacting with a twisted, double, blue strand of DNA that separates where it meets the RNA. A ...